Hostility, anxiety and depression caused by raised prolactin levels (hyperprolactinemia)

Raised prolactin levels (hyperprolactinemia) correlate positively with increased hostility, depression and anxiety.

According to iherb reviewers, Dopa Mucuna (Mucuna Pruriens) is an effective inhibitor of prolactin, as is SAM-e.

According to this: "http://serendip.brynmawr.edu/bb/neuro/neuro02/web2/tromero.html"

"Studies of men and women with elevated levels of prolactin report decreased sexual interest, arousal, orgasm as well as mood disturbances such as anxiety and depression."

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From "http://www.ncbi.nlm.nih.gov/pubmed/6891814"

"Depression and hostility in hyperprolactinemia.
Fava M, Fava GA, Kellner R, Serafini E, Mastrogiacomo I.
Abstract

1. Patients with hyperprolactinemia offer a unique opportunity to investigate the effects of prolactin on psychological states. Women with hyperprolactinemic amenorrhea rated themselves significantly more hostile, more depressed and more anxious than women with amenorrhea only and normal women. 2. The hyperprolactinemic patients were compared with a group of post-partum (7th day) women, matched for sociodemographic variables and prolactin levels. The post-partum women showed significantly less depression and anxiety than those with hyperprolactinemic amenorrhea but about the same levels of hostility. 3. Hyperprolactinemic males did not rate themselves more hostile and depressed than matched controls."

and here: "http://www.ncbi.nlm.nih.gov/pubmed/6483849"

"Prolactin, aggression and hostility: a discussion of recent studies.

Kellner R, Buckman MT, Fava M, Fava GA, Mastrogiacomo I.

Abstract

Several studies are summarized in which the relationship of high prolactin levels and self-rated anger-hostility was examined. The Symptom Questionnaire, a state measure which contains an anger-hostility scale, was included in all studies. Women with hyperprolactinemic amenorrhea were found to have higher hostility scores than amenorrheic women with normal prolactin levels. In another study, hyperprolactinemic women were found to have higher hostility scores than female family practice patients, random employees and there was a nonsignificant trend for higher hostility scores than in female nonpsychotic psychiatric outpatients. In both studies, depression and anxiety were also significantly higher. When bromocriptine, a prolactin lowering drug, was administered to hyperprolactinemic women in a double blind crossover study, there was a significant and progressive decrease of hostility, depression and anxiety while on bromocriptine, parallel with the decrease in prolactin and no change on placebo. Post-partum women who had high prolactin levels were significantly more hostile than a control group of employees and as hostile as hyperprolactinemic women. Hyperprolactinemic males were no more hostile than controls. The relationship of prolactin to post-partum aggression in mammals is briefly reviewed. The findings are inconclusive; in the three species studied, postpartum aggression is perhaps enhanced, but does not depend on high prolactin levels. There are no studies on the relationship of prolactin levels and violence in women. Hostility associated with high prolactin levels in postpartum women is perhaps a phylogenetic remnant which may have had the evolutionary advantage of protecting the young.

PMID:

 

6483849

 

[PubMed - indexed for MEDLINE]"

Rhodiola rosea can help reduce exaggerated startle responses, and Huperzine A can cause 'twitching' (myoclonus / hypnic jerks?), according to reviewers

Rhodiola rosea can help reduce exaggerated startle responses, and Huperzine A can cause 'twitching' (myoclonus / hypnic jerks?), according to reviewers

Rodiola is also good for energy, and those who don't get up well in the morning.

Huperzine A increases Acetycholine, and helps learning and memory.

The above form reviews at Swansonvitamins.com (for rhodiola) and iherb.com (for huperzine a)