Rhodiola rosea can help reduce exaggerated startle responses, and Huperzine A can cause 'twitching' (myoclonus / hypnic jerks?), according to reviewers

Rhodiola rosea can help reduce exaggerated startle responses, and Huperzine A can cause 'twitching' (myoclonus / hypnic jerks?), according to reviewers

Rodiola is also good for energy, and those who don't get up well in the morning.

Huperzine A increases Acetycholine, and helps learning and memory.

The above form reviews at Swansonvitamins.com (for rhodiola) and iherb.com (for huperzine a)

B6, Niacin etc for Autism - Double blind, crossover studies etc.

1. A practising doctor can report on case studies, which these doctors have done. They do not undertake RCT's. That is a different area of endeavour.
2. While a study, or a randomized control trial to be more exact, is "substantial proof" of something, it is not the only possible proof
3. The report of patients and doctors alike in this regard should reasonably lead everyone to *suspect* the efficacy of these treatments
4. The financial incentive to explore this area is non-existant
5. The role of B6 (pyroluria) and B12 (histadelia) in Autism has been studied formally, and PROVEN to be usefull/
6. Autism == Neurological disease of childhood,
7. Depression, anxiety and so on = Neurological disease of adulthood

Here is a quote from the book, "The Neurobiology of Autism"

"Vitamin B6 (pyridoxine) supplementation has been reported to improvebehavior in autism (Rimland, 1974). A subsequent double-blind, placebo-controlled trial supported the earlier report (Rimland et al., 1978). Discussing themetabolic approaches to the treatment of autism spectrum disorders, Page(2000) suggested that several well-designed studies, including Coleman (1989),Kleijnen and Knipschild (1991), and Lelord et al. (1988), supported the idea that pyridoxine improves some symptoms of autism."


Coleman N. 1989. Autism: non-drug biological treatments. In C Gilberg (ed.), Diagnosisand Treatment of Autism,pp. 219–35. New York: Plenum Press.

Coppen A, Chaudhry S, Swade C. 1986. Folic acid enhances lithium prophylaxis. J AffectiveDisord10:9–13.

Kleijnen J, Knipschild P. 1991. Niacin and vitamin B-6 in mental functioning: a review ofcontrolled trials in humans. Biol Psychiatry29:931–41.

Lelord G, Barthelemy C, Martineau N. 1988. Clinical and biological effects of vitamin B-6 plus magnesium in autistic subjects. In J Laklam and R Reynolds R (eds.), VitaminB-6 Responsive Disorders in Humans,pp. 329–56. New York: Liss.

Page T. 2000. Metabolic approaches to the treatment of autism spectrum disorders. JAutism Dev Disord30:463–69

Rimland B. 1974. An orthomolecular study of psychotic children. J Orthomol Psychiatry3:371–77.

Rimland B, Callaway E, Dreyfus P. 1978. The effect of high doses of vitamin B-6 on autis-tic children: a double-blind crossover study. Am J Psychiatry135:472–75.

Norethisterone (Primolut-N) causes impaired glucose tolerance and lowers the good HDL Cholesterol, as well as alpha-lipoproteincholesterol

Source: http://www.ncbi.nlm.nih.gov/pubmed/6811837

"Lipid metabolic studies in oophorectomised women: effects on serum lipids and lipoproteins of three synthetic progestogens.

Silfverstolpe G, Gustafson A, Samsioe G, Svanborg A.

"Abstract

Norethisterone acetate, medroxyprogesterone acetate and levonorgestrel were administered to oophorectomised women to evaluate the effects they have on lipid metabolism. Blood samples were drawn after a 3 wk period without hormone therapy and after 3 wk on each progestogen. Serum and lipoprotein lipids were followed and an oral glucose tolerance test with blood glucose and plasma insulin determinations were performed. The nortestosterone derivatives, norethisterone acetate and levonorgestrel, decreased high density lipoprotein cholesterol as well as alpha-lipoproteincholesterol, while the 17-hydroxyprogesterone derivative medroxyprogesterone acetate did not. Norethisterone acetate and medroxyprogesterone acetate impaired glucose tolerance. A difference between nortestosterone derivatives and 17-hydroxyprogesterone derivatives having an effect on high density lipoproteins is suggested."

Women with Interstitial Cystitis or Painful Bladder Syndrome have other conditions such as irritable bowel syndrome and fibromyalgia

"Many women with IC/PBS have other conditions such as irritable bowel syndrome and fibromyalgia. Scientists believe IC/PBS may be a bladder manifestation of a more general condition that causes inflammation in various organs and parts of the body."


source:http://kidney.niddk.nih.gov/kudiseases/pubs/interstitialcystitis/#cause

Stresses (including 'social subordination') increase serotonin and cortisol and result in 'less exploratory' and less 'spontaneous' behaviour

http://www.cnr.uidaho.edu/fish511/Readings/Readings%202010/nsl230.pdf

Boron causes elevation in estrogen (17 beta-estradiol) and testosterone, reduction in urinary excretion of magnesium and calcium, increases plasma copper, SOD, and ceruloplasmin, (the last three are also raised by estrogen therapy, but by a lesser degree is boron is insufficient), and "it is possible that high dietary intakes of boron or molybdenum could regulate the rate of catabolism, or even the metabolic fate of the major estrogens." (i.e., could prevent methylation of estrogen by COMT)

sources:
http://www.nlm.nih.gov/medlineplus/druginfo/natural/894.html
http://www.ncbi.nlm.nih.gov/pubmed/3678698
http://www.ithyroid.com/boron.htm

Boswellia caused a reversal in brain metastasis - the anti-cancer potential of boswellia serrata

source: http://www.pinestreetfoundation.org/avenues/avenues1920/stritter1920.html

"Subsequently, Dr. Flavin has had two more women with brain metastases greatly improve using the same regimen. Reportedly, Harvard's Dana Farber Cancer Center is seeking approval for a clinical trial to study boswellia use in this setting."

"BOSWELLIA USE IN BRAIN METASTASES

Last year, Dr. Dana Flavin at the Foundation for Collaborative Medicine and Research in Greenwich, CT, reported on a remarkable case of a woman with breast cancer whose multiple brain metastases showed no improvement after two weeks of Xeloda and brain radiation.2 She was then started on boswellia 800 mg three times a day. (Boswellia, also known as Indian frankincense, is an herbal supplement with anti-inflammatory properties and is generally available through retail and online health food stores.) Ten weeks later, a repeat brain CT showed complete resolution of the brain metastases. Impressively, she has been maintained on boswellia for the past four years with no recurrent brain metastasis.

Subsequently, Dr. Flavin has had two more women with brain metastases greatly improve using the same regimen. Reportedly, Harvard's Dana Farber Cancer Center is seeking approval for a clinical trial to study boswellia use in this setting."