Quercetin and genistein induce aromatase activity - one study

Quercetin and genistein induce aromatase activity - one study


Whereas other Flavanoids inhibited aromatase activity and some others first induced and then, at higher concentrations, inhibited aromatase.


Source: http://toxsci.oxfordjournals.org/content/82/1/70.abstract

The natural flavone quercetin and isoflavone genistein induced aromatase activity 4- and 2.5-fold induction, respectively, at 10 μM. This coincided with increased intracellular cAMP concentrations and increased levels of the cAMP-dependent pII and to a lesser extent 1.3 promoter-specific aromatase transcripts.