Adrenal fatigue syndrome often involves decreased DHEA-S.

Source: Adrenal Fatigue The 21st Century 86 Stress Syndrome©
by James L. Wilson ND, DC, Ph.D.
ISBN: 0-9843635-0-5 978-0-9843635-0-6
Page 86


"I also usually measure DHEA-S levels with the saliva test as well
because the adrenals are the primary source of DHEA-S (but not
necessarily DHEA). Adrenal fatigue syndrome often involves decreased
DHEA-S. The DHEA-S level is a direct indicator of the functioning of
the area within the adrenal glands that produces sex hormones (the zona
reticularis). Saliva tests for testosterone, the estrogens, progesterone
and other hormones can also be done, if needed, and may be of value in
working with adrenal fatigue. Testosterone and DHEA-S levels are two of
the most reliable indicators of biological age. Testosterone and DHEA-S
levels below the reference range for the person’s age may be indicators
of increased aging. If the cortisol levels are also decreased, the 3 tests
together further indicate chronically decreased adrenal function."