Does increased estrogen mean better absorption of zinc and magnesium, or does it create a higher requirement?

And what happens to zinc and magnesium and the issues associated with too little of them such as hypoglycemia and depression, when the cause of the excess estrogen (pill, pregnancy, menstrual, other) ends?

"The connection with estrogen, the female hormone Postnatal depression, depression during menopause and depression after stopping the anti-conception pills all have the same cause. These three situations have in common a decrease of estrogenvalues in the blood. After pregnancy the estrogen levels decrease, during menopause the estrogen levels decrease and after quiting the anti-conception pill the estrogen levels drop to normal levels (during pregnancy and anti-conception they are increased). Estrogen causes a higher absorption and use of magnesium and zinc. Estrogen is normally associated with pregnancy. During pregnancy the body needs more minerals en estrogen takes care of the higher absorption. The estrogen enables a female to get just enough magnesium out of a low-magnesium diet. When the estrogen levels drop, the magnesium absorption drops and hypomagnesemia (magnesium deficiency) is the result. This can then cause a severe depression or diabetes or hypoglycemia or many other problems. The anti-conception pill is often used to heal acne. Possibly this works because the estrogen increases absorption of zinc, which is essential for a healthy skin."

From http://www.newtreatments.org/depression

Tramadol, bupropion, and nortriptylin can cause seizures.

3 patterns of catamenial epilepsy have been identified - two different sources, possibly differing patterns

Source: Three patterns of catamenial epilepsy.

Scientific Journal: http://www.ncbi.nlm.nih.gov/pubmed/9579954


Source: PATTERNS AND CAUSES
Same authors, better presentation: http://professionals.epilepsy.com/page/catamenial_patterns.html

Progesterone's antiseizure effects are due to the progesterone metabolite allopregnanolone, which has powerful antiseizure activity

Progesterone's antiseizure effects are due to the progesterone metabolite allopregnanolone, which has powerful antiseizure activity.

"Cyclical changes of ovarian hormones estrogens and progesterone are now widely believed to be essential for the genesis of catamenial seizures. Generally, progesterone has antiseizure effects, while estrogens facilitate seizure susceptibility. The progesterone metabolite allopregnanolone has been identified as a key endogenous neurosteroid with powerful antiseizure activity. Allopregnanolone is a potent, positive allosteric modulator of GABA(A) receptors. Progesterone and allopregnanolone exposure and withdrawal affects GABA(A) receptor plasticity."


Source: Pharmacology of catamenial epilepsy.
By: Reddy DS.
Link: http://www.ncbi.nlm.nih.gov/pubmed/15538544


(Also from

Meyler's Side Effects of Endocrine and Metabolic Drugs

 By Jeffrey K. Aronson

)

Withdrawal from chronic progesterone and, consequently, of allopregnanolone levels in brain, has been shown to increase seizure susceptibility, possibly through the effect of the withdrawal on GABA(A) receptor plasticity

Title: Pharmacology of catamenial epilepsy.
source: http://www.ncbi.nlm.nih.gov/pubmed/15538544

For mass:
"In animal models, withdrawal from chronic progesterone and, consequently, of allopregnanolone levels in brain, has been shown to increase seizure susceptibility. Natural progesterone therapy is proven to be effective in women with epilepsy. Consequently, synthetic neurosteroids that are devoid of hormonal side effects represent a novel class of antiepileptic drugs for women with catamenial epilepsy. Our studies suggest that ganaxolone, a GABA(A) receptor-modulating synthetic neuroactive steroid, is a particularly promising treatment for catamenial epilepsy."

Low copper-binding proteins, ceruloplasmin and/or metallothionein, can lead to high unbound copper, and symptoms of both copper toxicity and copper deficiency.

Symptoms of excess copper include poor sleep, aggression/assaultive, poor concentration, PMS and sensitivity to tight clothes and tags

sources:
Title: http://drlwilson.com/articles/copper_toxicity_syndrome.htm (evernoted today)
Body: http://www.aph.gov.au/house/committee/ee/mentalhealth/subs/attach01.pdf (google docced today and yesterday)