Low copper-binding proteins, ceruloplasmin and/or metallothionein, can lead to high unbound copper, and symptoms of both copper toxicity and copper deficiency.

Symptoms of excess copper include poor sleep, aggression/assaultive, poor concentration, PMS and sensitivity to tight clothes and tags

sources:
Title: http://drlwilson.com/articles/copper_toxicity_syndrome.htm (evernoted today)
Body: http://www.aph.gov.au/house/committee/ee/mentalhealth/subs/attach01.pdf (google docced today and yesterday)