Progesterone's antiseizure effects are due to the progesterone metabolite allopregnanolone, which has powerful antiseizure activity.
"Cyclical changes of ovarian hormones estrogens and progesterone are now widely believed to be essential for the genesis of catamenial seizures. Generally, progesterone has antiseizure effects, while estrogens facilitate seizure susceptibility. The progesterone metabolite allopregnanolone has been identified as a key endogenous neurosteroid with powerful antiseizure activity. Allopregnanolone is a potent, positive allosteric modulator of GABA(A) receptors. Progesterone and allopregnanolone exposure and withdrawal affects GABA(A) receptor plasticity."
Source: Pharmacology of catamenial epilepsy.
By: Reddy DS.
Link: http://www.ncbi.nlm.nih.gov/pubmed/15538544
(Also from
"Cyclical changes of ovarian hormones estrogens and progesterone are now widely believed to be essential for the genesis of catamenial seizures. Generally, progesterone has antiseizure effects, while estrogens facilitate seizure susceptibility. The progesterone metabolite allopregnanolone has been identified as a key endogenous neurosteroid with powerful antiseizure activity. Allopregnanolone is a potent, positive allosteric modulator of GABA(A) receptors. Progesterone and allopregnanolone exposure and withdrawal affects GABA(A) receptor plasticity."
Source: Pharmacology of catamenial epilepsy.
By: Reddy DS.
Link: http://www.ncbi.nlm.nih.gov/pubmed/15538544
(Also from
Meyler's Side Effects of Endocrine and Metabolic Drugs
By Jeffrey K. Aronson
)
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